The border between EC and PER35 can be easily established based on cytoarchitectonic criteria, because in PER35 no lamina dissecans can be distinguished, a distinct feature of EC. Moreover, layers II and III of PER35 are characterized by the presence of lightly stained densely packed neurons. This results in an appearance that is quite different from the adjacent EC, where cells in layer II are larger and stain darker for Nissl and NeuN substance. The laminar differentiation in EC layers II and III is much more distinct. Using an antibody against the calcium-binding protein parvalbumin, the border between EC and PER35 of the perirhinal cortex stands out. While, the entorhinal cortex close to the border stains heavily positive for parvalbumin, an abrupt loss of staining is seen in the neighboring area 35. By contrast, a marked increase of staining for the calcium binding protein calbindin is noticeable in area 35.
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