The border of the caudal entorhinal area (CE) with the ventral-intermediate entorhinal area (VIE) & the dorsal-intermediate entorhinal area (DIE) is indicated by changes in the overall architecture in that the conspicuous lamina dissecans present in CE is less apparent in VIE & DIE. Layer III changes from having an overall regularly organization with equally spaced neurons in CE to a much more irregular layer in VIE & DIE where the neurons tend to be clustered with empty areas in between. The columnar like arrangements seen in layers V and VI of CE also breaks down in VIE & DIE such that the appearance of layers V and VI is more laminar. Layer II of VIE is much thinner that in CE, whereas in CE and DIE this layer has an overall comparable appearance. When comparing sections stained for parvalbumin, it is obvious that CE has very strong positivity contrasting with the moderate to weak staining in DIE and VIE respectively. Stainings for the presence of calbindin mark the border since in CE positivity is almost exclusive for layer II whereas in VIE & DIE staining is also present in layers I and III.
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